Table 1 Target genes of CTCF as an insulator

From: CTCF as a multifunctional protein in genome regulation and gene expression

Insulated genes

Function

Reference

α-globin

The aEHS-1.4 insulator element embedded in the chicken α-globin locus organizes chromatin and prevents gene expression through CTCF

43

HS4

HS4 (DNase hypersensitive site 4) is located in the β-globin LCR and blocks the influence of enhancers on distal promoters upon CTCF and cohesin binding

44

Rxrb

A 507-bp intergenic sequence that includes 11P was found to insulate the Rxrb promoter from the Col11a2 enhancer in a CTCF-dependent manner

45

  1. Abbreviations: CTCF, CCCTC-binding factor; LCR, locus control region.