Table 1 Target genes of CTCF as an insulator
From: CTCF as a multifunctional protein in genome regulation and gene expression
Insulated genes | Function | Reference |
---|---|---|
α-globin | The aEHS-1.4 insulator element embedded in the chicken α-globin locus organizes chromatin and prevents gene expression through CTCF | |
HS4 | HS4 (DNase hypersensitive site 4) is located in the β-globin LCR and blocks the influence of enhancers on distal promoters upon CTCF and cohesin binding | |
Rxrb | A 507-bp intergenic sequence that includes 11P was found to insulate the Rxrb promoter from the Col11a2 enhancer in a CTCF-dependent manner |