Figure 2
From: Epigenetic modulation as a therapeutic approach for pulmonary arterial hypertension
MicroRNA (miRNA) regulatory pathways implicated in the pathogenesis of pulmonary arterial hypertension (PAH). This figure provides an overview of the signaling pathways regulated by miRNAs, which are involved in the pathogenesis of PAH. Aberrant expression of miRNAs in pulmonary vascular cells such as pulmonary artery endothelial cells (PAECs), pulmonary artery smooth muscle cells (PASMCs) and fibroblasts by pathological factors leads to altered signaling pathways and contributes to the pathogenesis of PAH.
