Figure 3 | Experimental & Molecular Medicine

Figure 3

From: Transcriptional mutagenesis by 8-oxodG in α-synuclein aggregation and the pathogenesis of Parkinson’s disease

Figure 3

All the possible mutant amino acid sequences of α-SYN generated by 8-oxodG-driven TM. Upper line (wild type) represents the reference amino acid sequence of the wild-type protein: lower line (TM) shows amino acid changes can be caused by 8-oxodG- mediated transcriptional mutagenesis arising from misincorporated adenine instead of cytosine in the mRNA sequence during transcription (red); green letters designate reported a-SYN mutants (A30P, E46K, H50Q, G51D, A53E & A53T) in familial PD; and serine 87 and129 (blue) is the site of phosphorylation as seen during aggregation of the molecule.

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