Figure 4 | Experimental & Molecular Medicine

Figure 4

From: Vaccination with Klebsiella pneumoniae-derived extracellular vesicles protects against bacteria-induced lethality via both humoral and cellular immunity

Figure 4

Protective effect of K. pneumoniae EV immunization against K. pneumoniae infection. (a) Survival graph for determining the lethal dose of K. pneumoniae. Various doses (1 × 105, 1 × 106, 1 × 107 and 1 × 108 CFU) of bacteria were injected intraperitoneally into mice (n=10; *P<0.05 and **P<0.01, compared with the PBS-injected group). (b) Survival graph of 1 × 108 CFU of K. pneumoniae challenged mice after immunization with 0.5, 1 and 2 μg of K. pneumoniae EVs three times for 3 weeks at a 1-week interval (n=10; ***P<0.001, compared with the sham mice group).

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