Table 2 Frequency of parental TCRα chain in Vβ transgenic mouse models
From: Analyses of the TCR repertoire of MHC class II-restricted innate CD4+ T cells
Vβ transgenic mouse models: parental TCRα sequence | Reference | ||
|---|---|---|---|
OT-II TCR-derived TCRβ5.2 transgene: CAARGNRIFF (Vα2.3-Jα31) | Present data | ||
CD4 SP Thymocytes | Incidence | % of Pop. | |
T-T TCRmini | 1/376 | 0.27% | |
T-E TCRmini | 10/467 | 2.14% | |
TCRmini Tg | 4/137 | 2.92% | |
OT-I TCR-derived TCRβ5.2 transgene: CAASDNYQL (Vα2.3-Jα26) | |||
CD8 SP Thymocytes | Incidence | % of Pop. | |
Limited mice | 6/100 | 6.00% | |
MBP-specific TCR-derived TCRβ8.2 transgene: CAASANSG (Vα2.3-Jα11) | |||
MBP-TCRβ Transgenic | Incidence | % of Pop. | |
CD4 SP Thymocytes | 19/29 | 65.52% | |
CD8 SP Thymocytes | 0/21 | 0.00% | |
DN32H6 (NK1.1 + T cells)-derived TCRβ8.2 transgene: VVGDRGSA (Vα14-Jα281) | |||
CD4+Vβ8+ thymocytes | Incidence | % of Pop. | |
DN32H6β transgenic #1 | 15/17 | 88.24% | |
DN32H6β transgenic #2 | 14/18 | 77.78% | |
Transgene negative littermate | 15/23 | 65.22% | |
