Figure 2
From: The biological complexity of RKIP signaling in human cancers
(a) TRAIL-induced signalosome formation at the death receptor consisting of FADD and Caspase-8. RKIP enhances TRAIL-induced apoptosis by upregulating death receptors. (b) NF-κB activates Snail, which further inhibits RKIP. Inhibitor of Kappa B (IκB) inactivates NF-κB, and therefore SNAIL is inhibited. NPI-0052 has been shown to enhance IκB levels. LFB-R603 inhibits NF-κB and Snail. Snail is also inhibited by galiximab. (c) The YY1 protein transcriptionally downregulates DR5, whereas RKIP and galiximab inhibit the YY1 protein.
