Figure 1 | Experimental & Molecular Medicine

Figure 1

From: STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance

Figure 1

Effects of administration of morphine on STEP phosphorylation in dorsal striatum. Mice were injected with 20 mg kg−1 morphine (intraperitoneal). After 30 min, the dorsal striatum was obtained for western blot analysis of phospho-STEP and STEP (a). Significant differences between saline-treated groups and indicated groups at *P<0.05, (n=4–6 animals per group, Student’s t-test). Representative examples of neurons showing colocalization of STEP and MOR immunosignals in the dorsal striatum (b). Scale bar, 20 μm. MOR, μ-opioid receptor; NS, nonspecific.

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