Figure 3 | Experimental & Molecular Medicine

Figure 3

From: STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance

Figure 3

Morphine-induced analgesia, tolerance and psychological dependency in STEP+/+ and STEPC230X−/− mice. (a) The pain response on a 52 °C hot plate. Mice received morphine (10 mg kg−1, intraperitoneal) 30 min before the behavioral assay. (b) Repeated morphine treatment decreased the %MPE in both STEP+/+ and STEPC230X−/− mice. (c) The dwelling time spent in the white compartment before (pre-conditioning session) and after (post-conditioning session) morphine injection in the morphine conditioned place preference test. (d) The preference for each compartment was calculated by deducting the time of the pre-conditioning session in the saline–saline and saline–morphine-treated groups.Significant difference compared with wild type at #P<0.05 and significant difference between the indicated groups at **P<0.01 (n=6–10, Student’s t-test). MPE, maximum possible effect.

Back to article page