Figure 5 | Experimental & Molecular Medicine

Figure 5

From: STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance

Figure 5

Morphine-induced hyperlocomotion in STEP+/+ and STEPC230X−/− mice. (a) Time-course changes of morphine-induced hyperlocomotion in the open field in STEP+/+ and STEPC230X−/− mice. Each point represents the distance that mice moved in a 10-min block. (b) Summed locomotor activity for the 120-min period after morphine administration in STEP+/+ and STEPC230X−/− mice. Significant difference between indicated groups at *P<0.05 and **P<0.01, respectively (n=6–8 animals per group, two-way analysis of variance followed by Bonferroni post hoc test).

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