Figure 4
From: Gene-metabolite network analysis in different nonalcoholic fatty liver disease phenotypes
The functional network-based regulation model with genes and metabolites commonly regulated in different NAFLD phenotypes. This model includes modules of genes, metabolites and signaling pathways. Circle nodes represent genes; rhombus and triangle nodes represent metabolites in the liver and serum, respectively; borders of the nodes represent the types of gene and metabolites (that is, those that were upregulated are shown in red, and those that were downregulated are shown in green); genes that were not quantified are presented in gray; and blue filled square nodes indicate signaling pathways. The gene–gene and gene–metabolic interactions are depicted as gray solid line; dashed lines depict the linkage of genes to related signaling pathways.
