Figure 3
From: Adipose stem cell-derived nanovesicles inhibit emphysema primarily via an FGF2-dependent pathway
Regeneration effects of ASC-derived artificial nanovesicles on elastase-induced emphysema mice. C57BL/6 mice were intratracheally injected with elastase on day 0 and then intratracheally injected with ASC-derived artificial nanovesicles (Nano), natural exosomes (Exo) or ASCs on day 7. (a) Lung histology on day 14 after staining with hematoxylin and eosin. ((−) control: no elastase injection; Ela: 0.4 U of elastase injection; Ela+ASC: elastase+1 × 105 ASCs; Ela+Nano (1/3 ×): elastase+1/3 × artificial nanovesicles; Ela+Nano (1 ×): elastase+1 × artificial nanovesicles; Ela+Exo (1 ×): elastase+1 × exosomes). (b) Morphometric analysis of the mean linear intercept (n=8–12). The data were significantly different (*P<0.05, **P=0.0089, ***P=0.0001) between the elastase group and the groups with injected ASCs or artificial nanovesicles.
