Figure 5 | Experimental & Molecular Medicine

Figure 5

From: In vitro generation of mature midbrain-type dopamine neurons by adjusting exogenous Nurr1 and Foxa2 expressions to their physiologic patterns

Figure 5

TH+ cell graft formed by transplantation with NPCs transduced with Lenti-pUb-Nurr1+Retro-pLTR-Foxa2+Lenti-pUb-ca-PKA. Cortical NPCs transduced with Lenti-pUb-Nurr1+Retro-pLTR-Foxa2+Lenti-pUb-ca-PKA were transplanted into the striatum of a PD model rat. The brain was cryosectioned and stained with TH, and confocal images were taken at 4 weeks after transplantation. TH+ cells in the boxed areas were enlarged in the right panels. Scale bar, 100 μm. NPCs, neural stem/precursor cells; TH, tyrosine hydroxylase.

Back to article page