Figure 6 | Experimental & Molecular Medicine

Figure 6

From: Alectinib (CH5424802) antagonizes ABCB1- and ABCG2-mediated multidrug resistance in vitro, in vivo and ex vivo

Figure 6

Effect of alectinib on the inhibition of AKT, ERK and c-Met phosphorylation. The protein levels of AKT, ERK and c-Met were detected by western blot in KB (a, e), KBv200 (b, f), S1 (c, g) and S1-MI-80 (d, h) cells treated with alectinib at the indicated concentrations and designated time points. Alectinib (15.0 μM) was used as a positive control for the blockage of AKT, ERK and c-Met phosphorylation. Representative results from three independent experiments are shown in each panel.

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