Figure 3 | Experimental & Molecular Medicine

Figure 3

From: A polymorphic minisatellite region of BORIS regulates gene expression and its rare variants correlate with lung cancer susceptibility

Figure 3

Analysis of the core promoter of BORIS. (a) The upper panel shows the positions of putative binding sites for GATA-1 and the CCAAT box in the p700 vector, which had the highest expression in Figure 2b. This region represents the difference between the p678 and p700 vectors. The wild-type construct (p700) contained putative binding sites for GATA-1 and the CCAAT box, whereas the mutant constructs (GATA-1Δ#1, GATA-1Δ#2 and CCAATΔ) were mutated at the GATA-1 site or the CCAAT box in the p700 vector. (b) Luciferase activity of each vector is shown in the upper panel. The lower table shows the relative luciferase activity compared with control vector as the mean±s.e. and the P-values of at least four independent experiments.

Back to article page