Figure 4
From: Crucial role of HMGA1 in the self-renewal and drug resistance of ovarian cancer stem cells
HMGA1 expression regulates the CSC characteristics of A2780 ovarian cancer cells. (a) Time course of the cell numbers counted after plating the same number of cells (1 × 104 cells per well). A2780 spheroid cells with HMGA1 knockdown are compared with control A2780 spheroid cells (upper panel), and HMGA1-overexpressing A2780 adherent cells are compared with control A2780 adherent cells (lower panel). *P<0.05 (b) Bright-field images of spheroids generated from A2780 spheroid cells with or without HMGA1 knockdown (upper panels) and counts of the spheroid numbers (lower panel) are shown. Scale bar, 100 μm. *P<0.05 (c) Bright-field images of spheroids generated from HMGA1-overexpressing A2780 adherent cells in comparison with control A2780 adherent cells (upper panels) and counts of the spheroid numbers (lower panel) are shown. Scale bar, 100 μm. *P<0.05.
