Figure 4
From: IL-33 promotes IL-10 production in macrophages: a role for IL-33 in macrophage foam cell formation
Effects of IL-10 siRNA on IL-33-induced cellular cholesterol reduction and alterations of CD36 and ABCA1. (a) IL-33 reduced the cellular cholesterol content, which was abolished by IL-10 siRNA. (b, d, e) IL-33 downregulated whereas IL-10 siRNA had no effect on CD36 expression. (c, d, f) IL-33 increased IL-10 expression, which was diminished by siRNA against IL-10. *P<0.05 versus baseline (PBS treatment). These data represent three independent experiments. si-IL-10, siRNA against IL-10; si-Scr, siRNA with scramble sequences without any known target mRNA; TC, total cholesterol.
