Figure 6
From: IL-33 promotes IL-10 production in macrophages: a role for IL-33 in macrophage foam cell formation
Effects of IL-33 on IL-10 mRNA production, stability and gene promoter activity. (a) A transcription factor inhibitor, ActD, abolished the up-regulatory effects of IL-10 in MFCs. (b) IL-33 had a scarcely detectable influence on IL-10 mRNA stability. (c) IL-33 activated IL-10 gene promoter, as indicated by luciferase activity. (d) Promoter deletion analysis, which identified core sequences in the IL-33-induced IL-10 production process. *P<0.05 versus PBS treatment; #P<0.05 versus the pGL3-Basic. These data represent three independent experiments. ActD, actinomycin D; MFC, macrophage-derived foam cell.
