Figure 7
From: Therapeutic inhibition of SGK1 suppresses colorectal cancer
Therapeutic SGK1 inhibition upregulates p27 expression and represses tumor growth and cellular proliferation in the subcutaneous xenograft mice model. (a) The procedure of establishing a xenotransplant mouse model, followed by treatment with GSK650394; n=8. (b) p27 expression in xenograft tumor samples. (c, d) Transplanted tumor volume and size; n=8. (e) Ki67- and PCNA-positive cell populations in xenograft tumor tissues. Scale bars, 200 μm; *P<0.05; ***P<0.001.
