Figure 1 | Experimental & Molecular Medicine

Figure 1

From: Longitudinal exome-wide association study to identify genetic susceptibility loci for hypertension in a Japanese population

Figure 1

Single-nucleotide variants (SNVs) showing significant associations with hypertension. The associations were examined using the generalized estimating equation (GEE) model in the dominant (a), additive (b) and recessive (c) genetic models. The seven candidates of hypertension-associated SNVs shown in the figure were determined when the association was supported by the GEE model with normal and t reference distributions, and the approxdf value of these SNVs was higher than 30 (see text). The three GEE analyses independently tested the association between SNVs and three clinical parameters: prevalence of hypertension (HT); systolic blood pressure (SBP); and diastolic blood pressure (DBP). On the basis of Bonferroni’s correction, P-values of <8.54 × 10−7 for the dominant and additive models and P<1.29 × 10−6 for the recessive model were considered statistically significant. aAmino-acid change reflecting a point mutation at each SNV (nonsynonymous substitution).

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