Table 2 Seven candidate SNVs showing significant associations with the clinical parameters associated with hypertension
Trait/disease | Ref SNP ID | Position a | Gene or locus | Mutation | Genotype | All subjects b | Hypertension b | Controls b |
|---|---|---|---|---|---|---|---|---|
HT–SBP–DBP | rs12229654 | Chr12: 111 414 461 | 12q24.11 | Silent | TT | 15 908 (55.8%) | 5829 (60.5%) | 10 079 (53.3%) |
(T→G) | TG | 10 796 (37.8%) | 3323 (34.5%) | 7473 (39.6%) | ||||
GG | 1823 (6.4%) | 482 (5.0%) | 1341 (7.1%) | |||||
HT–SBP–DBP | rs3782886 | Chr12: 112 110 489 | BRAP | Synonymous (Arg241Arg) | TT | 13 297 (46.6%) | 5035 (52.3%) | 8262 (43.7%) |
(T→C) | TC | 12 380 (43.4%) | 3826 (39.7%) | 8554 (45.3%) | ||||
CC | 2852 (10.0%) | 773 (8.0%) | 2079 (11.0%) | |||||
HT–SBP–DBP | rs11066015 | Chr12: 112 168 009 | ACAD10 | Silent in intron | GG | 13 950 (46.6%) | 5258 (54.6%) | 8692 (46.0%) |
(G→A) | GA | 12 026 (43.4%) | 3691 (38.3%) | 8335 (44.1%) | ||||
AA | 2553 (10.0%) | 685 (7.1%) | 1868 (9.9%) | |||||
HT–SBP–DBP | rs671 | Chr12: 112 241 766 | ALDH2 | Missense (Glu303Lys) | GG | 13 939 (48.9%) | 5250 (54.5%) | 8689 (46.0%) |
(G→A) | GA | 12 026 (42.2%) | 3697 (38.4%) | 8329 (44.1%) | ||||
AA | 2564 (8.9%) | 687 (7.1%) | 1877 (9.9%) | |||||
HT–SBP–DBP | rs2074356 | Chr12: 112 645 401 | HECTD4 | Silent in intron | GG | 14 876 (48.9%) | 5498 (57.1%) | 9378 (49.6%) |
(G→A) | GA | 11 388 (42.2%) | 3546 (36.8%) | 7842 (41.5%) | ||||
AA | 2265 (9.0%) | 590 (6.1%) | 1675 (8.9%) | |||||
HT–SBP–DBP | rs11066280 | Chr12: 112 817 783 | HECTD4 | Silent in intron | TT | 13 409 (52.1%) | 5066 (52.6%) | 8343 (44.2%) |
(T→A) | TA | 12 338 (39.9%) | 3816 (39.6%) | 8522 (45.1%) | ||||
AA | 2782 (7.9%) | 752 (7.8%) | 2030 (10.7%) | |||||
SBP | rs11917356 | Chr3: 130 110 550 | COL6A5 | Missense (Asp982Gly) | GG | 2917 (48.4%) | 1787 (47.4%) | 1130 (50.2%) |
(G→A) | GA | 2494 (41.4%) | 1556 (41.2%) | 938 (41.7%) | ||||
AA | 611 (10.1%) | 430 (11.4%) | 181 (8.0%) |
