Figure 6 | Experimental & Molecular Medicine

Figure 6

From: RNF138-mediated ubiquitination of rpS3 is required for resistance of glioblastoma cells to radiation-induced apoptosis

Figure 6

Combination treatment of RNF138 knockdown and irradiation reduced tumor growth in GBM orthotopic xenograft mice models. (a) An experimental protocol to determine whether RNF138 knockdown increases in vivo radiosensitization in GBM orthotopic xenograft mice models. (b) Kaplan–Meier survival curves of orthotopic tumor-bearing mice (n=5 for each group) after implantation of normal U87MG or ΔRNF138 U87MG cells and radiation exposure. (c) Representative H&E staining images and IHC images for rpS3, RNF138 and GADD34 on tumor sections. Scale bars, 25 μm.

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