Figure 3
The functional preservation of Rheb(S16H) against the pKr-2-induced neurotoxic events in vivo. (a–c) The amounts of striatal dopamine and its metabolites, such as DOPAC and HVA, were measured by HPLC, and the level was quantitatively expressed as a percentage of the level in contralateral controls. *P<0.001 and **P<0.01 vs contralateral controls, #P<0.001 vs pKr-2 alone (one-way ANOVA and Tukey’s post hoc analysis; n=5, each experimental group). All values are expressed as the mean±standard error of the mean (s.e.m.). (d) Locomotor activity was measured with the rota-rod test. *P<0.05 vs control mice, #P<0.05 vs pKr-2 alone (t-test analysis; n=8, each experimental group). All values are expressed as the mean±s.e.m.
