Figure 2

Therapeutic effects of WA-25 on AD. (a) Protocol for induction of AD in BALB/c mice. (b) The photos of the control, AD, WA-25-treated (AD+W) and HC-treated (HC) groups were taken on day 15. (c) AD scores of the control, AD, AD+W and HC groups. (d) TEWL of the control, AD, AD+W and HC groups. (e) Scratching behavior of the control, AD, AD+W and HC groups. (f) Alloknesis scores of the control, AD, AD+W and HC groups. (g) Immunostaining of iNOS and HO-1 in the skin of animals from the control, AD and AD+W groups. *Significantly (P<0.05) different from the AD group. #Significantly (P<0.05) different from the AD+W group. Scale bar=50 μm. n=6 per group. AD, atopic dermatitis; TEWL, transepidermal water loss.