Figure 1

BTG2^/TIS21 expression is increased in normal mucous epithelium with H. pylori infection, but absent in stomach cancer cells. Immunohistochemistry (IHC) findings of BTG2^/TIS21 expression on the serial sections of normal mucosa and cancer tissues of the human stomach infected with H. pylori. (a) BTG2 expression was increased in the neck portion of gastric glands in the body of the stomach with H. pylori infection, × 200. (b) BTG2 expression was lost in adenocarcinoma despite the mild expression in normal mucous epithelium, × 40. Inset is the high-power view revealing no BTG2 expression in carcinoma cells. (c) Absence of BTG2 expression in mucous epithelium (arrows) compared with strong positive expression in the parietal cells (rectangle) of the human stomach without H. pylori infection, × 200. (d) Induction of BTG2 expression in the surface of mucous glands infected with many H. pylori (arrows), × 400. (e) To confirm the secretion of Tipα and H. pylori infection, serial sections of paraffin blocks were stained. Note mild (panel ii) to strong (panel iii) expression of Tipα and H. pylori in the mucous glands of the stomach with H. pylori (arrows) infection but no Tipα expression (panel i) in the mucous glands of the stomach without H. pylori infection (arrow heads), × 400.