Figure 6 | Experimental & Molecular Medicine

Figure 6

From: MicroRNA-708-3p as a potential therapeutic target via the ADAM17-GATA/STAT3 axis in idiopathic pulmonary fibrosis

Figure 6

Clinical research of miR-708-3p in patients with IPF. (a) TEM showed an increased collagen amount in the patients with IPF relative to that in the normal subjects. (b) qRT-PCR confirmed that miR-708-3p expression was lower in the peripheral blood mononuclear cells of the patients with IPF than in those of the normal individuals. (c, d) MiR-708-3p levels positively correlated with FVC% and DLco%. Statistical analysis was performed using the Pearson correlation coefficient. (e, f) Immunofluorescence revealed that ADAM17 expression increased significantly in the patients with IPF compared with normal individuals. (g) Pearson correlation coefficient showed that miR-708-3p inversely correlated with ADAM17 in patients with IPF. Each bar represents mean±s.d.; n=6. ***P<0.01 compared with the normal group.

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