Figure 6
From: A FKBP5 mutation is associated with Paget’s disease of bone and enhances osteoclastogenesis
Micro-CT analysis of femurs from FKBP51WT and FKBP51V55L homozygous mice. (a) Analysis of trabecular bone parameters analysis. Bone volume, trabecular number and tubercular thickness were decreased in FKBP51V55L mice; accordingly, trabecular spacing and trabecular pattern factor increased in FKBP51V55L mice compared with the WT control. However, the average cortical wall thickness in WT and mutant mice shows no significant difference. *P<0.05; **P<0.01. (b) Longitudinal micro-CT sections of femurs from FKBP51WT and FKBP51V55L mutant mice. In the distal femur of the FKBP51V55L mouse, the trabeculae are more sparse and thin than those in the wild-type animal. However, no significant cortical thickening or expansion of the femur from FKBP51V55L mouse is apparent, and no bending deformity of the long bone is seen. (c) Micro-CT analysis with 3D reconstruction of the distal femur and the proximal tibia of a FKBP51WT mouse and of two FKBP51V55L mice. The two mutant mice show suspicious focal osteolytic lesions penetrating the cortex (orange arrows), whereas the same area in the wild-type mouse does not show this phenotype.
