Table 3 Allele and genotype distributions of IL28B SNPs in 728 Taiwanese chronic HCV infection patients and 960 normal controls

From: IL28B genetic variations are associated with high sustained virological response (SVR) of interferon-α plus ribavirin therapy in Taiwanese chronic HCV infection

SNP marker

Risk allele

RAF (normal)

RAF (HCV)

Ptrend

Genotypes/alleles

Age, sex adjusted

      

P-value

OR (95% CI)

rs28416813

C

0.975

0.999

1.0 × 10−6

C/G+G/G vs C/C

1.5 × 10−5

0.012 (0.002–0.089)

     

G vs C

6.4 × 10−7

0.026 (0.006–0.110)

rs8099917

T

0.936

0.947

0.2006

G/G vs G/T+T/T

0.0010

0.034 (0.004–0.254)

     

G vs T

0.0425

0.713 (0.515–0.989)

  1. Abbreviations: CI, confidence interval; HCV, hepatitis C virus; OR, odds ratio; RAF (normal) and RAF (HCV), risk allele frequency in normal controls and HCV patients; SNP, single-nucleotide polymorphism.
  2. Ptrend value were calculated by the Cochran–Armitage trend test with permutation=100 000.
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