Table 5 Association of IL28B SNPs with SVR in Taiwanese patients with chronic HCV infection

From: IL28B genetic variations are associated with high sustained virological response (SVR) of interferon-α plus ribavirin therapy in Taiwanese chronic HCV infection

SNP marker

Risk allele

RAF (NR)

RAF (SVR)

Ptrend

Genotypes/alleles

Age, sex adjusted

Stepwise logistic regression

      

P-value

OR (95% CI)

P-value

OR (95% CI)

rs4803219

C

0.899

0.966

2.0 × 10−6

C/T vs C/C

3.7 × 10−7

0.258 (0.153–0.435)

1.4 × 10−7

0.191 (0.103–0.354)

     

T vs C

7.4 × 10−7

0.284 (0.172–0.467)

2.1 × 10−7

0.213 (0.119–0.382)

rs12979860

C

0.891

0.966

1.0 × 10−6

C/T+T/T vs C/C

4.4 × 10−8

0.236 (0.140–0.395)

3.1 × 10−8

0.181 (0.099–0.331)

     

T vs C

3.5 × 10−8

0.252 (0.155–0.411)

2.9 × 10−8

0.200 (0.113–0.353)

rs11881222

A

0.894

0.964

1.0 × 10−6

A/G+G/G vs A/A

2.1 × 10−7

0.256 (0.153–0.428)

1.1 × 10−7

0.195 (0.107–0.356)

     

G vs A

1.6 × 10−7

0.272 (0.167–0.443)

9.0 × 10−8

0.214 (0.121–0.376)

rs12980275

A

0.899

0.959

4.9 × 10−5

A/G+G/G vs A/A

3.4 × 10−6

0.302 (0.182–0.500)

2.0 × 10−6

0.241 (0.134–0.433)

     

G vs A

1.0 × 10−5

0.340 (0.211–0.549)

4.3 × 10−6

0.275 (0.158–0.476)

rs8105790

T

0.896

0.962

9.0 × 10−6

C/C+C/T vs T/T

1.3 × 10−6

0.282 (0.169–0.471)

5.5 × 10−7

0.222 (0.123–0.400)

     

C vs T

9.5 × 10−7

0.298 (0.184–0.484)

7.5 × 10−7

0.248 (0.143–0.431)

rs8099917

T

0.896

0.962

5.0 × 10−6

G/G+G/T vs T/T

9.6 × 10−7

0.277 (0.165–0.462)

4.3 × 10−7

0.217 (0.120–0.392)

     

G vs T

7.1 × 10−7

0.293 (0.180–0.476)

6.2 × 10−7

0.245 (0.141–0.426)

rs7248668

G

0.896

0.964

4.0 × 10−6

A/A+A/G vs G/G

6.1 × 10−7

0.268 (0.160–0.450)

3.6 × 10−6

0.246 (0.136–0.445)

     

A vs G

4.5 × 10−7

0.283 (0.173–0.462)

4.5 × 10−6

0.270 (0.154–0.472)

rs10853728

C

0.746

0.924

0.0015

G/G+C/G vs C/C

0.0007

0.533 (0.371–0.767)

0.0006

0.485 (0.322–0.731)

     

G/G vs C/G+C/C

0.0109

0.330 (0.141–0.775)

0.0117

0.291 (0.111–0.759)

     

G vs C

0.0002

0.564 (0.418–0.761)

0.0002

0.527 (0.375–0.740)

  1. Abbreviations: CI, confidence interval; HCV, hepatitis C virus; NR, no response; OR, odds ratio; RAF, risk allele frequency; SNP, single-nucleotide polymorphism; SVR, sustained virological response.
  2. Risk allele, the allele with higher frequency in cases compared with controls.
  3. Ptrend value was calculated by the Cochran–Armitage trend test with 100 000 permutations.
Back to article page