Table 6 Association of IL28B haplotypes with SVR in patients with chronic HCV infection

From: IL28B genetic variations are associated with high sustained virological response (SVR) of interferon-α plus ribavirin therapy in Taiwanese chronic HCV infection

Haplotype

Frequency

Associated haplotype

EM algorithm*

Logistic regression a

Stepwise logistic regression

 

SVR−(N=169)

SVR+(N=559)

 

P-value

95% CI

P-value

95% CI

P-value

95% CI

rs11881222+rs4803219+rs12979860

0.891

0.964

ACC

<0.0001

3.31 (2.08–5.27)

6.7 × 10−8

3.80 (2.34–6.16)

4.1 × 10−8

4.82 (2.75–8.44)

 

0.098

0.033

GTT

<0.0001

0.32 (0.20–0.51)

1.3 × 10−6

0.29 (0.17–0.48)

3.8 × 10−7

0.22 (0.12–0.39)

rs12980275+rs8105790

0.887

0.949

AT

0.0001

2.36 (1.53–3.62)

1.1 × 10−5

2.73 (1.74–4.27)

5.0 × 10−6

3.32 (1.99–5.53)

rs12980275+rs8105790+rs11881222

0.885

0.949

ATA

0.0001

2.43 (1.58–3.72)

6.0 × 10−6

2.80 (1.79–4.36)

4.0 × 10−6

3.34 (2.00–5.56)

rs8105790+rs11881222

0.884

0.954

TA

<0.0001

2.73 (1.76–4.22)

1.0 × 10−6

3.15 (2.00–4.96)

4.0 × 10−7

3.88 (2.29–6.55)

  1. Abbreviations: CI, confidence interval; EM, expectation maximization; HCV, hepatitis C virus; OR, odds ratio; SVR, sustained virological response.
  2. a Adjusted for sex and age.
  3. *P-value with 10 000 permutations.
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