Table 2 MiRNAs with significant differential expression levels between T-cell subsets
Cluster I: naive Tconv | ||||||
|---|---|---|---|---|---|---|
Geomean expression array data | Min–max | Change vs naive Tconv (%) | ||||
miRNA | naive Tconv | Memory Tconv | Memory Treg | Naive Treg | Naive Tconv | |
miR-7g | 66 | 54–78 | 87% | 46% | 78% | 100% |
miR-29c | 32 | 28–38 | 65% | 27% | 61% | 100% |
miR-342-3p | 26 | 24–27 | 72% | 45% | 78% | 100% |
miR-26a | 18 | 13–21 | 64% | 24% | 66% | 100% |
miR-142-5p | 17 | 14–22 | 95% | 49% | 46% | 100% |
miR-146b-5p | 13 | 10–19 | 59% | 36% | 50% | 100% |
miR-30b | 7.3 | 6.0–7.9 | 70% | 28% | 72% | 100% |
let-7b | 6.9 | 6.2–7.7 | 112% | 50% | 81% | 100% |
miR-363 | 2.4 | 1.5–4.3 | 20% | 0.3% | 23% | 100% |
let-7c | 1.3 | 1.1–1.8 | 94% | 43% | 61% | 100% |
miR-31 | 1.1 | 0.8–1.5 | 44% | 0.3% | 26% | 100% |
miR-151-5p | 1.0 | 0.8–1.3 | 31% | 2% | 37% | 100% |
miR-590-5p | 1.0 | 0.8–1.2 | 79% | 39% | 48% | 100% |
miR-423-5p | 0.3 | 0.2–0.4 | 89% | 17% | 82% | 100% |
Cluster II: naive | ||||||
|---|---|---|---|---|---|---|
Geomean expression array data | Min–max | Change vs naive Treg (%) | ||||
miRNA | Naive Treg | Memory Tconv | Memory Treg | Naive Treg | Naive Tconv | |
miR-92a | 4.7 | 3.5–5.7 | 63% | 46% | 100% | 87% |
miR-342-5p | 2.2 | 1.9–2.7 | 79% | 50% | 100% | 107% |
miR-320d | 2.1 | 1.7–2.3 | 65% | 48% | 100% | 81% |
miR-320e | 1.4 | 1.1–1.7 | 70% | 42% | 100% | 87% |
miR-4299 | 1.4 | 1.0–1.4 | 66% | 40% | 100% | 74% |
miR-320c | 1.3 | 1.0–2.0 | 71% | 44% | 100% | 91% |
miR-1275 | 0.6 | 0.3–0.8 | 72% | 16% | 100% | 86% |
Cluster III: Treg | ||||||
|---|---|---|---|---|---|---|
Geomean expression array data | Min–max | Change vs naive Treg (%) | ||||
miRNA | Naive Treg | Memory Tconv | Memory Treg | Naive Treg | Naive Tconv | |
miR-146a | 20 | 9–34 | 35% | 100% | 91% | 5% |
miR-3162 | 2.1 | 0.6–4.2 | 50% | 100% | 88% | 37% |
miR-1202 | 1.9 | 0.4–5.9 | 32% | 100% | 97% | 23% |
miR-1246 | 0.9 | 0.1–3.1 | 9% | 100% | 135% | 6% |
miR-4281 | 0.8 | 0.2–1.7 | 68% | 100% | 107% | 40% |
Cluster IV: memory | ||||||
|---|---|---|---|---|---|---|
Geomean expression array data | Min–max | Change vs naive Treg (%) | ||||
miRNA | Naive Tconv | Memory Tconv | Memory Treg | Naive Treg | Naive Tconv | |
miR-21 | 104 | 73–150 | 100% | 179% | 33% | 29% |
miR-16 | 44 | 32–58 | 100% | 118% | 48% | 55% |
miR-15b | 10 | 6–14 | 100% | 130% | 45% | 63% |
miR-15a | 6.7 | 4.0–9.2 | 100% | 103% | 35% | 43% |
miR-23a | 5.0 | 4.0–6.2 | 100% | 63% | 44% | 53% |
miR-24 | 4.9 | 4.0–6.8 | 100% | 81% | 38% | 39% |
miR-27a | 4.1 | 3.2–5.5 | 100% | 61% | 30% | 50% |
miR-22 | 2.7 | 1.2–3.2 | 100% | 86% | 15% | 22% |
miR-155 | 2.2 | 1.9–4.4 | 100% | 157% | 53% | 29% |
miR-425 | 0.7 | 0.6–0.9 | 100% | 95% | 49% | 74% |
miR-4306 | 0.6 | 0.5–0.7 | 100% | 103% | 30% | 71% |
miR-148a | 0.5 | 0.4–0.7 | 100% | 87% | 26% | 109% |
miR-222 | 0.5 | 0.2–0.4 | 100% | 43% | 4% | 34% |
miR-625 | 0.4 | 0.3–0.6 | 100% | 73% | 29% | 82% |
miR-7 | 0.3 | 0.3–0.5 | 100% | 112% | 37% | 65% |
miR-454 | 0.2 | 0.1–0.3 | 100% | 166% | 3% | 47% |
