Table 1 TDT analysis of full, centromeric and telomeric KIR haplotypes for type 1 diabetes association with stratification by DR3/4 status
From: KIR haplotypes are associated with late-onset type 1 diabetes in European–American families
KIR Haplotype a | Trans | N-trans | TDTtest b | P-valuec | Trans % | OR (95% CI) |
|---|---|---|---|---|---|---|
A B full, non-DR3/4 | ||||||
A1 | 236 | 183 | 6.70 | 0.0096 | 56.3% | 1.29 (1.06–1.56) |
A2 | 91 | 91 | 0.00 | 1.00 | 50.0% | 1.00 (0.75–1.34) |
B | 283 | 314 | 1.61 | 0.20 | 47.4% | 0.90 (0.77–1.06) |
Others | 37 | 59 | 5.04 | 0.0247 | 38.5% | 0.63 (0.42–0.95) |
A B full, DR3/4 | ||||||
A1 | 128 | 121 | 0.20 | 0.66 | 51.4% | 1.06 (0.83–1.36) |
A2 | 53 | 53 | 0.00 | 1.00 | 50.0% | 1.00 (0.68–1.46) |
B | 185 | 198 | 0.44 | 0.51 | 48.3% | 0.93 (0.76–1.14) |
Others | 31 | 25 | 0.64 | 0.42 | 55.4% | 1.24 (0.73–2.10) |
Cen haplotypes, non-DR3/4 | ||||||
cA01 | 421 | 381 | 2.00 | 0.16 | 52.5% | 1.10 (0.96–1.27) |
cB01 | 109 | 117 | 0.28 | 0.59 | 48.2% | 0.93 (0.72–1.21) |
cB02 | 80 | 90 | 0.59 | 0.44 | 47.1% | 0.89 (0.66–1.20) |
Others | 37 | 59 | 5.04 | 0.0247 | 38.5% | 0.63 (0.42–0.95) |
Cen haplotypes, DR3/4 | ||||||
cA01 | 232 | 220 | 0.32 | 0.57 | 51.3% | 1.05 (0.88–1.27) |
cB01 | 67 | 87 | 2.60 | 0.11 | 43.5% | 0.77 (0.56–1.06) |
cB02 | 67 | 65 | 0.03 | 0.86 | 50.8% | 1.03 (0.73–1.45) |
Others | 31 | 25 | 0.64 | 0.42 | 55.4% | 1.24 (0.73–2.10) |
Tel haplotypes, non-DR3/4 | ||||||
tA01 | 324 | 266 | 5.70 | 0.0169 | 54.9% | 1.22 (1.04–1.43) |
tA02 | 142 | 149 | 0.17 | 0.68 | 48.8% | 0.95 (0.76–1.20) |
tB01 | 144 | 173 | 2.65 | 0.10 | 45.4% | 0.83 (0.67–1.04) |
Others | 37 | 59 | 5.04 | 0.0247 | 38.5% | 0.63 (0.42–0.95) |
Tel haplotypes, DR3/4 | ||||||
tA01 | 181 | 189 | 0.17 | 0.68 | 48.9% | 0.96 (0.78–1.17) |
tA02 | 93 | 98 | 0.13 | 0.72 | 48.7% | 0.95 (0.71–1.26) |
tB01 | 92 | 85 | 0.28 | 0.60 | 52.0% | 1.08 (0.81–1.45) |
Others | 31 | 25 | 0.64 | 0.42 | 55.4% | 1.24 (0.73–2.10) |
