Table 2 TDT analysis of full, centromeric and telomeric KIR haplotypes for type 1 diabetes association with stratification by age of onset
From: KIR haplotypes are associated with late-onset type 1 diabetes in European–American families
KIR Haplotype a | Trans | N-trans | TDTtest b | P-valuec | Trans % | OR (95% CI) |
|---|---|---|---|---|---|---|
A B full, age onset⩽14 | ||||||
A1 | 265 | 228 | 2.78 | 0.10 | 53.8% | 1.16 (0.97–1.39) |
A2 | 96 | 117 | 2.07 | 0.15 | 45.1% | 0.82 (0.63–1.07) |
B | 362 | 361 | 0.00 | 0.97 | 50.1% | 1.00 (0.87–1.16) |
Others | 45 | 62 | 2.70 | 0.10 | 42.1% | 0.73 (0.49–1.07) |
A B full, age onset >14 | ||||||
A1 | 95 | 70 | 3.79 | 0.0516 | 57.6% | 1.36 (1.00–1.85) |
A2 | 45 | 26 | 5.08 | 0.0241 | 63.4% | 1.73 (1.07–2.80) |
B | 102 | 146 | 7.81 | 0.0052 | 41.1% | 0.70 (0.54–0.90) |
Others | 20 | 20 | 0.00 | 1.00 | 50.0% | 1.00 (0.54–1.86) |
Cen haplotypes, age onset ⩽14 | ||||||
cA01 | 472 | 453 | 0.39 | 0.53 | 51.0% | 1.04 (0.92–1.19) |
cB01 | 139 | 147 | 0.22 | 0.64 | 48.6% | 0.95 (0.75–1.19) |
cB02 | 112 | 106 | 0.17 | 0.68 | 51.4% | 1.06 (0.81–1.38) |
Others | 45 | 62 | 2.70 | 0.10 | 42.1% | 0.73 (0.49–1.07) |
Cen haplotypes, age onset >14 | ||||||
cA01 | 173 | 140 | 3.48 | 0.0621 | 55.3% | 1.24 (0.99–1.54) |
cB01 | 37 | 56 | 3.88 | 0.0488 | 39.8% | 0.66 (0.44–1.00) |
cB02 | 32 | 46 | 2.51 | 0.11 | 41.0% | 0.70 (0.44–1.09) |
Others | 20 | 20 | 1.00 | 1.00 | 50.0% | 1.00 (0.54–1.86) |
Tel haplotypes, age onset ⩽14 | ||||||
tA01 | 375 | 333 | 2.49 | 0.11 | 53.0% | 1.13 (0.97–1.31) |
tA02 | 166 | 191 | 1.75 | 0.19 | 46.5% | 0.87 (0.71–1.07) |
tB01 | 182 | 182 | 0.00 | 1.00 | 50.0% | 1.00 (0.81–1.23) |
Others | 45 | 62 | 2.70 | 0.10 | 42.1% | 0.73 (0.49–1.07) |
Tel haplotypes, age onset >14 | ||||||
tA01 | 123 | 112 | 0.51 | 0.47 | 52.3% | 1.10 (0.85–1.42) |
tA02 | 66 | 55 | 1.00 | 0.32 | 54.5% | 1.20 (0.84–1.72) |
tB01 | 53 | 75 | 3.78 | 0.0518 | 41.4% | 0.71 (0.50–1.00) |
Others | 20 | 20 | 0.00 | 1.00 | 50.0% | 1.00 (0.54–1.86) |
