Table 1 Risk genes for latitude-dependent autoimmune diseases are highly overrepresented in the vitamin D receptor cistrome
Study (GWAS catalog no.) | Total risk SNPs | DC1 peaks overlap | DC1 P-value | DC2 peaks overlap | DC2 P-value | CD14 peaks overlap | CD14 P-value | Latitude effect? | Vit D deficiency? |
|---|---|---|---|---|---|---|---|---|---|
Inflammatory bowel disease (23128233) | 110 | 29 | 4.8E−18 | NS | NS | Khalili et al.7 | Del Pinto et al.12 | ||
Ulcerative colitis (21297633) | 47 | 13 | 3.7E−09 | NS | 2 | 2.11E−02 | Khalili et al.7 | Del Pinto et al.12 | |
Multiple sclerosis (21833088) | 81 | 16 | 1.2E−08 | 3 | 3.30E−03 | 3 | 6.88E−03 | Simpson et al.10 | Nieves et al.13 |
Crohn's disease (21102463) | 69 | 14 | 6.9E−08 | NS | 5 | 2.07E−05 | Khalili et al.7 | Jørgensen et al.14 | |
HDL cholesterol (20686565) | 47 | 10 | 3.2E−06 | 2 | 1.28E−02 | NS | Grimes et al.53 | NA | |
Mean platelet volume (22139419) | 29 | 8 | 3.9E−06 | 4 | 3.82E−06 | 2 | 8.37E−03 | Icli et al.54 | Cumhur Cure et al.55 |
Celiac disease (20190752) | 40 | 9 | 6.2E−06 | 4 | 1.42E−05 | 3 | 9.20E−04 | NA | Tavakkoli et al.15 |
Fibrinogen (23969696) | 23 | 7 | 7.8E−06 | NS | NS | Grimes et al.53 | NA | ||
HDL cholesterol (24097068) | 71 | 11 | 2.6E−05 | 2 | 2.77E−02 | NS | Grimes et al.53 | NA | |
Rheumatoid arthritis (20453842) | 28 | 7 | 3.2E−05 | NS | NS | Vieira et al.8 | Hong et al.16 | ||
ADHD (23527680) | 21 | 6 | 5.3E−05 | NS | NS | Arns et al.56 | Humble et al.57 | ||
Multiple sclerosis (19525955) | 8 | 4 | 8.3E−05 | 1 | 2.87E−02 | NS | Simpson et al.10 | Nieves et al.13 | |
Crohn's disease (23850713) | 8 | 4 | 8.3E−05 | 1 | 2.87E−02 | NS | Khalili et al.7 | Jørgensen et al.14 | |
Multiple sclerosis (19525953) | 15 | 5 | 1.0E−04 | NS | NS | Simpson et al.10 | Nieves et al.13 | ||
Systemic lupus erythematosus (23273568) | 34 | 7 | 1.2E−04 | NS | NS | Walsh and Gilchrist9 | Mok17 |
