Evaluation of Prenatal Screening Program for Down Syndrome analysis of 96 cases of Down syndrome for last 10 years

Abstract

The purpose of this study was evaluation of efficiency of prenatal screening program for Down syndrome using various screening methods (Age: greater than or equal to 35 years old. Serum markers: Triple test, Ultrasonography: abnormal sono findings, Nuchal translucency, Nuchal fold thickness). Total 96 cases of Down syndrome were prenatally or postnatally diagnosed between Jan 1990 and Sept. 1999. The frequencies of diagnosed Down syndrome were 68 (71 %) in prenatal and 28 (29 %) in postnatal The mean age ot mother of Down syndrome fetus was 33.0 ± 0.6 years old The frequency rate of Down syndrome was 04, 13, 07, 07, 16, 0.7, 12, 2.2, 2.0 and 23 a 1,000 deliveries from 1990 to 1999 (Y-0.28+0.18 year, P=0.01). The percenl of prenatal Down syndrome was 0 (0/2), 43 (3/7), 50 (2/4), 25 (1/4), 56 (5/9), 100 (5/5), 71 (5/7). 78 (14/18) and 89 (17/19) from 1990 to 1999 (Y= 129+89 year, P=0.000). The contribution rate of prenatal diagnosis for Down syndrome was 302±5.6 % by age, 18.2±3.4 % by triple test and 51.7±6.3 % by ullrasonography, and was significantly dilference among each screen methods (P=0.008) In conclusion, this study shows that our prenatal screening program is highly effective and the frequency rate of prenatal diagnosis for Down syndrome has been increased year by year for last 10 years.