Fig. 1
From: Cessation of enzyme replacement therapy in Gaucher disease
Effect of ERT, discontinuation and reinstitution in Patient 1. Histograms represent percent change in platelets (PLT), hemoglobin (HGB), ACE, spleen volume, and liver volume after 3 years of ERT, followed by 1 year off therapy and 4.5 years of reinstituted ERT. Dosages during the first 3 treatment years were 60 U/kg/2 weeks the first year, 15 U/kg/2 weeks the second year, and 60 U/kg/2 weeks the third year. The patient resumed therapy at 15 U/kg/2 weeks and remained at this dose for the ensuing 4.5-year period. Percent changes were calculated by subtracting values at the end of intervention from basal values divided by basal value times 100. (See Table 1.)
