Fig 8 | Genetics in Medicine

Fig 8

From: Nevoid basal cell carcinoma (Gorlin) syndrome

Fig 8

Classical model for regulation of SMO activity by PTCH and Hh. Both genes are membrane bound. Hedgehog is modified by both palmitate (PAL) and cholesterol (CHOL), freeing SMO for downstream signaling. (Based on MM Cohen, Jr. Am J Med Genet 2003;123A:5–28.)

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