Fig. 1

Pedigree of a four-generation Caucasian family with haplotypes of seven markers. Generation number is indicated by the bold-faced Roman numerals listed to the left of the generation. Individual identification number of each member is indicated at the right bottom side of each member. Markers and their corresponding locations are indicated in the lower-left corner. Italicized numbers in haplotypes (e.g., IV-1 and IV-2) were deduced alleles from the parent's haplotype, and “−”denotes that the genotypes for those markers were not available.