Fig. 4
From: Development and validation of a CGH microarray for clinical cytogenetic diagnosis
Microarray analysis, partial karyotype, and FISH comparison for case K3 [46,XX,inv dup(8)(p11.23p23.1)]. Partial karyotype showing inv dup 8p (4A). Microarray profile of the combined data (4B) reveal a loss of four clones (printed in red) in the array corresponding to the 8p23.3 region and a gain of one clone (printed in blue) in the 8p22 region. In addition, an unanticipated finding of a gain for two clones in the subtelomeric region of 18q was identified by microarray analysis (4B) and confirmed by FISH analysis (4C), which demonstrated that the additional copy of 18q material was located at the distal short arm of the inv dup chromosome 8; red probe is 18qter and green probe is 18pter.
