Fig. 1
Case 1: (A and B) Frontal view and profile of fetus at 22 weeks (three-dimensional ultrasound). Note frontal bossing, mild hypertelorism, prominent long philtrum, and micrognathia. (C and D) Sagittal and axial single-shot fast spin-echo T2-weighted sections from prenatal magnetic resonance imaging study showing frontal bossing (black arrow) and subcutaneous edema and thickening (asterisk). (E and F) Fetal features at postmortem examination. Evidence of peculiar craniofacial dysmorphisms: synophrys, small nose with anteverted nostrils, smooth and prominent philtrum, thin lips, microretrognathia, and low-set posteriorly rotated ears. (G) Close-up of fetal hand: brachydactyly and clinodactyly of the fifth finger. (H) Gross view of supernumerary spleens in the gastrosplenic ligament (white triangles) and histologic section of ectopic splenic tissue (white arrow) in pancreatic parenchyma (black arrow).
