Fig 1

Health-related quality of life in the CSMC Fabry heterozygote cohort compared to U.S. female norms, as measured by the SF-36 health survey. The mean composite and subcategory scores of the cohort are all below population norms. There is no overlap between cohort and normal 95% confidence intervals in the subcategories with the largest effect sizes (*physical functioning, general health, and vitality).