Fig 2

Phenotypes of biallelic GJB2 genotypes, based on presence or absence of 35delG. Individuals were classified according to their reported genotypes (35delG homozygous, 35delG compound heterozygous with a second GJB2 variant, and compound heterozygous with two non-35delG GJB2 variants) and their reported phenotype. Unclassifiable refers to individuals for whom phenotypic information was available but was difficult to categorize. If hearing loss was reported as consecutive ranges (such as mild to moderate), the more severe phenotype was reported. The severity of hearing loss was nonrandomly distributed among the three genotype classes (P = 0.0069, Cochran-Mantel-Haenszel test).