Fig 1 | Genetics in Medicine

Fig 1

From: The discovery of microdeletion syndromes in the post-genomic era: review of the methodology and characterization of a new 1q41q42 microdeletion syndrome

Fig 1

Results for chromosome 1 using a targeted microarray. Each clone on the plot is arranged along the x-axis according to its location on the chromosome with the most distal 1p telomeric clones on the left and the most distal/telomeric 1q clones on the right. The dark blue line represents the control:subject fluorescence intensity ratios for each clone, whereas the pink line represents the fluorescence intensity ratios obtained from a second hybridization in which the dyes have been reversed (subject:control). (A) Normal plot for chromosome 1. Note that all data points are at a log2 ratio of zero. (B) Plot for Subject 2 showing a deletion from BAC RP11-1031M6 through BAC RP11-61M2. (C) Plot for Subject 3 showing a deletion from BAC RP11-1148E24 through BAC RP11-61M2. (D) Plot for Subject 1 showing a deletion from BAC RP11-208F18 through RP11-61M2. For each of the plots B, C, and D, the deletion is identified as a mirror image deviation from a log2 ratio of zero to a log2 ratio of 0.3 to −0.3.

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