Fig. 2 | Genetics in Medicine

Fig. 2

From: Dose-response relationships for enzyme replacement therapy with imiglucerase/alglucerase in patients with Gaucher disease type 1

Fig. 2

Platelet count dose responses to enzyme therapy. A, Nonlinear mixed model showing the dose-response relationships of matched patients for platelet count. The Emax values were 1.97, 2.01, and 2.10 from baseline for Group A (5 to <29 U/kg/2 weeks), Group B (29 to <48 U/kg/2 weeks), and Group C (48 to <75 U/kg/2 weeks) dosing groups, respectively, corresponding to an approximately 2-fold increase in platelet count by 96 months. In each dosing group, the total number of data points after matching were 1679 for Group A (red), 1850 for Group B (black), and 1411 for Group C (blue). B, Table of calculated values for maximal effect from baseline (Emax) and time to 50% of maximal effect (T50). The P values and 95% confidence intervals are as in Figure 1B.

Back to article page