Fig. 3
Splenic volume dose responses to enzyme therapy. A, Nonlinear mixed model showing the dose-response relationships of matched patients for splenic volume. The Emax values were 0.32, 0.22, and 0.10 from baseline for the Group A (5 to <29 U/kg/2 weeks), Group B (29 to <48 U/kg/2 weeks), and Group C (48 to <75 U/kg/2 weeks) dosing groups, respectively, corresponding to reductions of 68%, 78%, and 90% in splenic volumes. The number of data points in each dosing group after matching was 521 for Group A (red), 482 for Group B (black), and 347 for Group C (blue). B, Table of calculated values from (A) for maximal effect from baseline (Emax) and time to 50% of maximal effect (T50) responses to splenic volume. The P values and 95% confidence intervals are as in Figure 1A.
