Fig. 4
Hepatic volume dose responses to enzyme therapy. A, Nonlinear mixed model showing the dose-response relationships of matched patients for hepatic volume. The Emax values were 0.61, 0.49, and 0.31 from baseline for the Group A (5 to <29 U/kg/2 weeks), Group B (29 to<48 U/kg/2 weeks), and Group C (48 to <75 U/kg/2 weeks) dosing groups, respectively, corresponding to reductions of 39%, 51%, and 69% in hepatic volumes. In each dosing group, the numbers of data points after matching were 527 for Group A (red), 472 for Group B (black), and 340 for Group C (blue). B, Table of calculated values from (A) for maximal effect from baseline (Emax) and time to 50% of maximal effect (T50) responses to hepatic volume. The P values and 95% confidence intervals are as in Figure 1, B.
