Figure 3
From: Laboratory testing of CYP2D6 alleles in relation to tamoxifen therapy
A graphic representation of the distribution of plasma endoxifen levels in women treated with tamoxifen, stratified by the three main cytochrome P450 2D6 metabolic phenotypes. The data sources and analytic methods are described in the text. (a) The relative distributions (same area under the curve for each distribution) for the poor (PM), intermediate (IM), and extensive (EM) metabolizer phenotypes. Although the mean levels are clearly different, there is important overlap, especially between the IM and EM phenotypes. (b) The same data, but incorporating the prevalence of each of the phenotypes into the figure (area under the distribution represents the proportion of the population with that phenotype).
