Figure 4 | Genetics in Medicine

Figure 4

From: Genotypic classification of patients with Wolfram syndrome: insights into the natural history of the disease and correlation with phenotype

Figure 4

Correlation of phenotype with genotypic classification in Wolfram syndrome. Box-plot representation of patient onset age distribution for each genotypic class and feature. White or black lines in the boxes indicate the median (2nd quartile); box limits show P75 (3rd quartile, top) and P25 (1st quartile, bottom). Outliers (1.5–3× interquartile range) are indicated as circles, and extremes (>3× interquartile range) are indicated as asterisks. Maximum and minimum are indicated by the top and bottom whisker ends, respectively. Number of patients in each category is indicated above x-axis (n). Genotypic classes are A1, A2, A3, B, and C. The probability of different means in each clinical feature, calculated using the Kruskal–Wallis test, is presented. Significant values are in red and values close to significance in bold. For detailed statistics, see Supplementary Table S8 online. DE, deceased; DI, diabetes insipidus; DM, diabetes mellitus; HD, hearing defects; ND, neurological, psychiatric, or developmental defects; OA, optic atrophy; UD, urological or renal defects.

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