Figure 5 | Genetics in Medicine

Figure 5

From: Genotypic classification of patients with Wolfram syndrome: insights into the natural history of the disease and correlation with phenotype

Figure 5

Progression rate of Wolfram syndrome. The progression rate of patients with Wolfram syndrome with three or more clinical features sorted by the age of onset is calculated as the slope of the linear regression that binds them. Median ± SEM is shown for each genotypic class inside the histograms. The slope was calculated from 21 patients in class A1; 7 in class A2; 133 in class A3; 49 in class B; and 70 in class C. The median slope ± SEM for all the patients (n = 260) is shown as a dashed line and gray area, respectively. Slopes that are higher than the population median show slower progression rates than the general population, and those that are smaller show faster progression rates. *P = 0.009.

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