Figure 1 | Genetics in Medicine

Figure 1

From: Recommendations from the EGAPP Working Group: does PCA3 testing for the diagnosis and management of prostate cancer improve patient health outcomes?

Figure 1

Observed consensus receiver operating characteristic (ROC) curves for prostate cancer antigen 3 gene (PCA3) scores and total prostate-specific antigen (tPSA) elevations (reprinted from the Agency for Healthcare Research and Quality Evidence Report).25 The open circles (solid line) indicate the consensus observed performance of PCA3 scores, while the filled circles (solid line) indicate the matched consensus observed tPSA performance. The dashed line indicates where the sensitivity equals 1 − specificity, indicating a test with no predictive ability. For each study, the sensitivities of PCA3 and tPSA at preselected false-positive (1 − specificity) rates (x axis) were estimated from the published ROC curves; median consensus sensitivities were derived for each (1 − specificity) rate (y axis).

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