Figure 1

Analytic frameworks. (a) Clinical scenario 1 shows the use of a multigene panel to estimate lifetime risk of developing type 2 diabetes (T2D) and improve patient outcomes. (b) Clinical scenario 2 shows the use of TCF7L2 testing in a high-risk population to determine short-term (3–4 year) risk of developing T2D and improve outcomes. The numbers correspond to the key questions contained in Table 1 .